I had pretty much similar adventures with CCleaner removing saves and NVDA not reading the text in Internet Explorer.
I used Firefox to play at first, but then NVDA stopped reading the text or Firefox blocked the use of Flash extension and I switched to Internet Explorer until it, too, stopped working.
Regarding the mod, I think the author wants to implement the original game first.
Not sure if stuff from other mods will be implemented.
For now I recommend Corruption Of Champions 2.

I am still wondering why the game works for you and stopped working for me.
Could uninstalling Flash Player be the reason?
I think not, but who knows?
Does someone know an accessible program that still can play Flash files?
I welcome any ideas of what to try.

@defender I'm using nvda.
I navigate using the arrows and the tab key, just like a web page.

Yes, the game should read like a webpage, which it did for me until recently.
Now I am unable to enter browse mode in NVDA.
Some buttons are unlabelled unfortunately, but I eventually managed to remember what did what.
So, for me it was like this:
In the main game, after the location description two buttons did nothing and I have no idea what they were for.
After that was main menu, with buttons to start a new game and save and load the game.
After the menu was data, with saving and loading.
After that was character appearance, Mailbox and finally, the list of perks.
After that the button to level up if applicable and buttons to read back a few fragments of the previous text.
I think that was all from the unlabelled buttons, give or take.
Buttons like exits, NPCs, Storage, Inventory were always labelled.
Another thing not accessible is the Codex.
I always had to use OCR in NVDA to select a topic.
The fact that NVDA recognized only part of the object did not help.
And some Codex entries are required to read if a player wants to use some questionable items, or enter some locations.
The worst part, in my opinion, are minigames, because we are unable to pass them without cheating.

Well they do have a discord and a comment section for each new update, so if the three of us got together and started (politely) asking about it now and then, keeping the pressure up without bombarding them, it would probably help.

We could ask in comments after the next update about the port appears.
I think Dark asked about accessibility some time ago and was told no.
But that was regarding Flash version, so maybe something changes in the new port.
So far there was no concrete information about when it be released.
I will probably wait until they release something playable.
Or would asking now be better?
Here is the link to their Discord:
https://www.fenoxo.com/discordchat/

As regards trials in tainted space, yeah, I was told accessibility wouldn't be happening, but if it's already in Coc 2 then there might be reason for asking again.
on the plus side, I had a look at the mod which luel mentioned in post 24.
It looks really awesome, actually slightly easier to use than the original with it's screen reader reader mode, nothing clunky about perk choice etc.

I don't know how incomplete it is, since when I was poking around, I could get up to finding amelie and the town ruins as well as Whitney's farm no problem.
The only thing which did strike me as a little weird was that I unlocked other explorable places by just using the explore button over and over again, where as before I thought you needed to be a certain level to unlock the desert and the mountain.

I'm going to update the database with info about the mod, and will have a look at Coc 2 as well, since if it's got a screen reader mode and skipable minigames that would be a great reason to add it.

Edit: Okay have updated the CoC db page, plus from the looks of it, the mod is pretty complete, I was even able to try out some of the alternative character names listed in the CoC wiki which seemed to work.

True, if you hear anything as regards Trials in tainted space,let me know, when I tried, the constant need to count unlabeled buttons, which didn't always seem to be in the same place made the game less than friendly to play.

I'm actually really interested in where Adev's CoC1 mod will go, since the developer mentioned something about adding more content to the game.

Back in 19 when I was playing CoC, there was a fascinating looking expansion which included things like weapon crafting, which would be cool, since in a lot of ways in CoC, it's the world and all the wonderfully weerd things you can do that interested me more than the erotica, although I didn't really like the way that levelling started to take quite large amounts of xp once you passed level 15 or so.

@caio: developers are working on remaking the game in another engine, since Flash stopped being supported.
It is the javascript port.
Regarding accessibility, I admit I am unsure how to bring up the topic.
I do not have any programming knowledge and have no idea what could or could not be made accessible.

@Defender I looked at the old topics concerning Trials in tainted space accessibility from a few years ago. Unfortunately, Fenoxo literally refused to discuss the matter since he stated it would take rewriting the UI. I sent him a private message at that time explaining that adding a few button labels was hardly a rewrite, and he never replied.

Given that I'm seeing a large amount of access related discussions as regards the CoC mod and CoC 2, (the CoC mod topic even links to someone bringing up the matter of Trials in tainted space accessibility on the Fenoxo forum), I'm not sure how much in this case the issue is about developer awareness of the problem, and how much about developer unwillingness to actually do anything.

Generally speaking in the past when I've had this sort of negative reception from developers, it's a sign to move on to something else, especially with the great work that people are putting in to the CoC mod and CoC 2 at the moment.

CoC 2 is my top priority as regards text games now, since it needs a db entry, I'll also admit I'm also tempted to replay CoC 1 and see if I can finally defeat Lethice, since previously I got past the second dungeon, acquired several lovers and was level 15, but didn't quite get to taking on the demon queen herself.

Again, if there are any indications that Fenoxo's attitude has changed, that would be awesome, so let us know, and if I get around to giving Trials in Tainted space a look over I'll put my ore in on the forum.

As I said, Trials In Tainted Space used to work for me and it still works for caio.
The game was possible to read as a webpage.
I have no clue what happened with it.
@Dark, how are you going to play COC 1 again?
Do you have a reliable way to run Flash files?
I would like to play it again and TITS if possible.
Good luck with COC 2.
Feel free to ask in case of any questions.

Okay, CoC2 has a db page, Find it here.

If there's any major info which people who have played more of CoC2 think should be included on the page to make new player's lives easier, let me know.

Now I need to decide whether to continue my game of CoC2 (I've just recruited Brent), or make another assault on Lethice with the original CoC mod.