Skullgirls is an indie fighting game that has been made completely accessible. If you haven't played other fighters (Street fighter, tekin, killer instinct), a fighter is a genre in which two characters face off in a two dimensional playing surface, and you are looking at the characters from the side, much like a sidescroller. Controls consist of a number of attack buttons that operate your character's hands and feet. In the case of skullgirls, three buttons perform punches and three perform kicks. In addition to these "normal" attacks, each character possesses a number of special moves which take longer to execute, but do more damage or have special properties (teleportation, ability to hit a character in the air,or fire long range projectiles among others.) Characters also have some kind of meter that allows them to perform even more powerful moves. In sg they're called blockbusters, and they're even more powerful specials. That's the basics of what a fighter is, but there's a whole lot more to have fun with. I highly recommend this game to anyone looking to dip their feet into the mainstream world. I tried to make tutorial videos about sg, but the first one sounded so horrible that I was discouraged from publishing it or continuing with the project. I've never been good at talking to a camera.
It's also worth noting that the game is available for xbox and ps4, though I don't recommend this since you'll be missing out on the amazing screen reader support implemented specifically for us.