Well as it stands right now, I don't think it can be changed other than a complete overhaul of the way items are handled. But I would leave items that are significant in the same place, such as quest items, and leave random spawning to the smaller items that are less significant; lower level weapons and gear, plants, etc. Highest level weapons like the meteoric or heroic weapons would only be purchasable for higher prices from the blacksmith, and a few more shops seling higher level and more expensive magical gear wouldn't be a bad idea either. But as I've said before, as someone who mainly comes from playing action rpgs where items are usually pretty fixed, my opinion may be a little scued. AHC is the first experience I've had with what I would call a more traditional rpg, because prire to this, there haven't been any that I could play. That aside though, I have no qualms starting the game over. I just really wish I knew where all my gear came from so I could have a reasonably good chance of finding my way back to my current outfit and gearset. haha.
Discord: clemchowder633