I can say from personal experience that this game isn't playable solo-- you'll need sighted assistance for navigation. However, as previously stated in this thread, you have a few options for that.
1) Play online with a sighted friend who can kind of shepard you through the dungeon. They can also help with your skill loadout.
2) Play split-screen with a friend in person, and your character will follow theirs as they move around. That friend can also help you with your inventory and skill load out as needed.
Visual barrier aside, it's a really fun game. You can lock on to enemies by holding down the left trigger (on Xbox 1) so that takes a lot of the guess-work out of the equation in regard to aiming.
Aside from that, I don't really know a good way of navigating the dungeons. It's not something that you can exactly put a guide together for, either. There are static areas that always stay the same, but for the most part, the dungeons are randomly generated as you walk on to the floor. So, to use one in-game example, your Catacombs won't be the same thing as my catacombs-- my dungeon might have two branching passages, while yours is just one giant straight-shot room.
Therefore, my final verdict on this is.. Slightly accessible? The combat and teamwork is great, the story is fantastic, and the character classes are really fun to play around with. However, you absolutely need sighted assistance to play this game. There's no way around that. And really, it's only playable to the extent i'm talking about on console versions as far as i'm aware. The PC version is more of a point-and-click sort of affair.