@Rory, most odd, my lady has a windows 7 machine and the latest version of Ie, ie 11 and had no problems.
I can't speak about Jaws as my only experience was with a very much older version quite a long while ago, it wasn't positive but then again I only spent an afternoon tinkering and that more for curiosity than a real desire to use the thing (especially with it's price tag).
I used Supernova for many years but I've been just plane disappointed at it's windows 10 support, especially since the screen reader that used to be renowned for reading any and all on screen text back in the xp days now only works with specifically configured bits of windows, and not even all of those (eg windows 10 email). I've got it on this desktop and still run the update from time to time to see where the sub versions of v 16 are going, I haven't even bothered installing it on my laptop and I don't know if I will or won't bother getting v17, then again with Supernova the most I would have to pay for a version upgrade would be about 200 quid so I can always go back to it in the future if needs be.
I have however been using Nvda all year and have been very happy with it and now consider it my main screen reader.
With browsers I've never liked firefox with it's complications and system slow and am mainly happy with ie, however it is getting be a concern that a lot of modern html5 games and sites aren't working with ie. Microsoft should really do their job and update the thing properly, and no, I don't mean Microsoft edge with it's ridiculously silly tabs, endless adverts and insane layout.
I have considered trying chrome for some of the things ie won't do, though that is another topic.
With our dreaming and singing, Ceaseless and sorrowless we! The glory about us clinging Of the glorious futures we see,
Our souls with high music ringing; O men! It must ever be
That we dwell in our dreaming and singing, A little apart from ye. (Arthur O'Shaughnessy 1873.)