I thought I was never going to be able to beat the game and am just too addicted now. Though it was hard but especially, needed much thinking and concentration and adrenaline and strategy well, everything that an excellent game does have. For the person asking about the last boss, the bio control system... it attacks in multiple ways. Its actually better if you take some time and learn those things by yourself, (its definitely more rewarding) but oh well. You can skip the rest of this post if you don't want spoilers!:
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1. It launches energy at you. or more like energy balls. you can just jump over those
2. It throws like 10 lime balls at once. you can and should have stun recovery available. plenty of them.
3. It launches electricity. you can jump over it as well, but its more tricky. A defense drink should be helpful on those stages.
Be aware that it has this annoying habit of teleporting as well.
As for attacking those bosses at t the end, including the bio control system and life burner and master battery ETC.. I used a combination of weapons, for me the triple yoyo (kind of slow, longer range) and the omega shooter (closer range, faster shooting but lower damage caused) do wonders. Yes, you have to grind and craft yourself one, at stage 16. Its pretty useful. It does 500 or so damage to the strongest bosses which are 25-4 and 25-5, but you can usually blast the omega shooter and take some damage and you will most likely be fine. You should take those stages slowly and think about your strategy. Use the sonar and hook on the very last level... those platforms are of great help when destruction comes.
ah yes, and I forgot to point out that curiously, the bio control system drops a recovery ring.. you just have to damage it with something that will not destroy objects... or stop shooting right after it dies.