Lately I haven't bothered using antivirus, but Defender on Win 10 actually does work. However I found it took over and found a fair number of false positives on my drives and machines. There's no real way to disable it either unless you go into the registry and do it, which is a pain because the keys may not have adequate permissions for you to do that. It was a nightmare but I eventually disabled it. I just can't be bothered to deal with its always running in the background. But if you just want protection, I think for the novice Defender is at least a great start. How effective it actually is in practice is something I don't know.
Ever since I used Win 7 I've never used an antivirus and I've never gotten infected. The best antivirus, I'd say, is common sense. Don't click on links or download something that sounds like it's too good to be true, or just looks odd. If you do want protection, I'd say Malware Bytes is a good solution. I also use two other programs, JRT and AdwCleaner, to kill spyware, adware and other annoying things. None of these are antivirus but they all are useful to have around, and they all are either free or have free editions. Malware Bytes has a paid realtime protection suite but I don't know how good it is. Imho it's better to have protection when you need it but to not rely on it, which is why I've drifted away from antivirus. If booting from a disc or reformatting your machine wasn't so difficult as a blind person, I'd say have a Windows dVD at the ready so that you can use it whenever you suspect you're infected. But that's still not the easiest thing in the world. Back when I was on Win7 I used a DVD image which comes pre-loaded with NvDA which I used to reinstall Windows. I've heard that Win10 is making this possible natively, similar to how Apple does with Voiceover. I really do hope it happens.
Make more of less, that way you won't make less of more!
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