Sorry about the delay in reposting. To answer you, yes they will work in the 32-bit systems. I run XP home/SP3 32-bit and i have no issues with the software installation (that is OS based that is).

I ended up getting the USB version of the Fatal1ty. A couple of issues I did find. First off, they aren't true 5.1 (which by the way they were advertised, I thought they were). I haven't really been able to test teh simulated 5.1 yet as 1. I had to reinstall Win XP just the other day, and haven't gotten my games installed yet, and 2. it seems that Windows has totally dumped and won't let me boot into it at all, so...

there are a couple of issues I found (for me at least) is that my screen readers (JAWS 9, JAWS 10, and even an last ditch attempt with MS Narrator) wouldn't let me click/select anything on step 2 of the installation. I had to have my girlfriend come over and select which country I live in, and then click "Next" on that screen. After that, I think I was able to make the rest of the choices on my own. There is one other problem, but that will come later.

Now, for a quick review. I did manage to get a little gaming (very very little, but an attempt). I tried it with Shades of doom. There are a couple of settings that have to be set up in the control panel to get the simulated 3-D sound, but from what little I messed with, it sounded decent. Going from 2 channel though, to 5.1 sum sound, it is going to take a little getting used to. The music sound great compared to the crap sound that (most) windows standard cards/drivers put out. It's almost the difference between listening to an AM radio station versus a brand new CD.The highs are nice and clear, and the bass rumbles (that is IF that is what you want). I can also wear them for hours and hours and hours on end and only get  minor irritation. The headband is soft and comfy (for me at least) and the ear cups are decently sized and also padded with fabric instead of leather/plastic/whatever else they use for that. They aren't true circum-oral as advertised, but they do cover enough of my ears to block out most other sound. The only problem in comfort I found (and this is probably because my ears are just funky somehow) is that my left ear gets a little sore after many many many hours of wearing (but I also have my right ear off so I can hear around me a lot of the time).

The main configuration panel is accessible with JAWS. You don't really have to use any special cursors to get to anything. This is where you go to set up the simulated 3-d/5.1 channel, the crystalizer (which is another sound filter that makes things way better) and the Effects for your surround. It's simple. You select the tab you want, tab to a check box for on or off, and then make adjustments with arrows. Done and done.

As for setting up your EQ... That area of the console is totally inaccessible. Again, "girlfriend... heeeeelp!" no JAWS9/10 pc cursor, no JAWS cursor, no MS Narrator working. Once you get that though, there isn't anything else that you should need sighted help for.

The software bundle that comes with it (the "extra" stuff, not the needed software" is, just as usual for creative, either totally inaccessible or so much a pain to use with JAWs that it isn't worth it.

All in all, I like them a lot. Great sound, easy adjustment  to the crystalizer/surround amount/sound effect (room effects), and comfort. I haven't tried the mic either yet, but eventually when I hop onto skype or something, we'll see (or if I find a game I like that has voice chat in it, that would be awesome too). Unfortunately though, if you can't get sighted help, and rely on JAWS completely, then don't go Creative (unless you just get the normal headphones with a 3.5 mm jack). I don't understand why they can't just code all of their stuff in one programming language. I mean, the software that gets integrated with Windows Sound options is accessible, the software to set up the simulated surround is accessible, so why can't the bundled software/installation/EQ settings be accessible? I'll stop there before it turns into a rant or what not. Hope that helps.