Quest has a very friendly interface when it detects JAWS is loaded. You will not need to code basic object and room properties, but you'll have to do it with randomization, world model change according to user choices.

What about Inform? It requires a lot of learning and coding even on Inform 7 which has a natural language similar to English sentences, but is very flexible and the generated games, both for Glulx and Z virtual machines, can be played on a considerable number of platforms including Windows, Mac, GNU/Linux, web browsers, Android, iOS, palm and many currently unused operating systems like MS-DOS and RISC OS.
Adrift is a commercial language whose IDE is easy to use, but I could'nt play games generated with this system using JAWS. Unless I didn't realize of an important setting, this system's interpreter seems to be inaccessible.

Well, I'm downloading the new version of Inform to see how it looks on the Mac.

if I were to do this, I'd use Inform 7.  You get a ridiculous amount of stuff for free that I've not seen elsewhere.  If it's an RPG, going and learning Inform 6 might be better--but this is more programming rather than describing, and is a c-like language as opposed to an essay-like language.
The built-in I7 interpreter isn't accessible, but you can easily launch the games in other interpreters for testing; I don't remember how I did it, but I actually got the I7 IDE to launch Frotz TTS back in the day.  The error reporting is fantastic, and, unless you know programming, it's probably what you want.

Well, I couldn't find nvda add on for adrift though.

That is just for playing, not developing.
If anybody can tell me how to tell the I7 ide to launch an accessible interpreter on the Mac, such as Spatterlight, that'd be great.
Unfortunately, Mac users no longer have a completely accessible interpreter. Zoom is abandonware, and Gargoil, which comes highly recommended, is completely inaccessible.