Hi, I'll try to help you get started, although I'm not really good at dos commands either, but navigating through folders isn't that hard.
I am not sure witch version of Talking-dosbox you have downloaded, I have the one that comes with win3.1 and window eyes. That's irrelavant at this point, but the reason why i'm saying this is because you need to install something called Com0com, that may, or may not, be packaged with the version you have. In my case, it was. Com0com is a serial port emulator that makes the screen reader we're going to be using think that there's a Braille en speak connected to your computer. I think there's steps in the readme file that comes with the package to help you set that up.
If you have set it up already, or you find the instructions and can folow them, we can continue and actually play some stuff. Or perhaps, if there's anything wrong, let me know and I'll try to help.