Though you can't use some detailed locational strategies, however, you can still play the game, at least for me I could play it.
The first thing to do is choose a map you want to play and memorize the map. You can ask sighted people to help you, or you can navigate the map by yourself. But navigating the entire map is really a time consuming process. Another way to achieve this is creating your own map, with your style.
2. memorize all hotkeys for your favorite race. For me, my favorite race is protoss so I know all hotkeys for that race, like build hotkeys, unit commands etc.
3. Use ctrl 1 to ctrl 0 and shift 1 to shift 0. These are used for making unit groups and building groups.
Also see
http://wiki.teamliquid.net/starcraft2/Hotkeys
This link contains useful informations on hotkeys.
And finally you need to make your own strategies for gaming. You may not be able to do everything in the game, but you can build, attack, use some strategies if you get used to it, etc.
Hope this helps.