I'm not all that used to using Notepad++, you can open a python command line using "Run", though thats not really practical for running whatever script you may be writing. Although, you could also use Run to use python for opening your script like "C:\python27\python.exe yourscript.py", but unless you put in something to pause your script and have it wait before closing, the command line window it opens will close right after, at least thats what happens when I try it.

Alternatively you could just keep a command line window open to your working directory and use python there to run your saved script. You could also try out PythonWin, which is packaged with Pywin32, the output seems to be screen reader friendly though may not share much of the features of Notepad++